NSAID's are drugs that inhibit prostoglandin systhesis and used as anti-inflammatory drugs. In General term, they are drugs that we use as "pain killers". Paracetamol has relatively liitle anti-inflammatory activity, unlike other common analgesics such as Aspirin and Ibuprofen(Brufen). Therefore it is not generally classified as an NSAID.
Other than Paracetamol there are so many NSAIDs that are used for different conditions.
ex: Salicylates
- Aspirin
- Diflunisal
- Methyl Salicylate topical
- Ibuprofen
- Naproxen
- Ketoprofen
- Fenoprofen
- Indomethacin
- Sulindac
- Ketarolac
- Diclofenac
- Piroxicam
- Meloxicam
- Tenoxicam
- Mefenemic acid
- Tolfenamic Acid
But none of these NSAIDs are recommended during First Trimester of Pregnancy. and even after that time period NSAIDs should not be used as a regular pain killer in pregnancy. Do you know why?
You know when a baby growing inside mother's womb, he does not breath by his own. He breaths what his mother breaths. So his lungs are not functioning until he comes out. DA(ductus arteriosus) is a blood vessel connecting the pulmonary artery to the proximal descending aorta. Development of DA is happening in the first trimester of pregnancy. and this process can be blocked by NSAIDs. Because to develop the DA prostaglandin activity is essential. So it is strictly contra-indicated in first trimester. But in late pregnancy, indomethacin is prescribed to close the DA, or to delay the labour in some conditions.
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